High prevalence of non-dipping patterns among black Africans with uncontrolled hypertension: a secondary analysis of the CREOLE trial

Abstract Background Dipping of blood pressure (BP) at night is a normal physiological phenomenon. However, non-dipping pattern associated with hypertension mediated organ damage, secondary forms and poorer long-term outcome. Identifying may be useful in assessing risk, aiding the decision to investigate for causes, initiating treatment, assisting decisions on choice timing anti-hypertensive therapy, intensifying salt restriction. Objectives To estimate prevalence factors determine effect three 6-months regimens dipping among Black African hypertensive patients. Methods This was analysis CREOLE Study which randomized, single blind, three-group trial conducted 10 sites 6 Sub-Saharan countries. The participants were 721 patients, aged between 30 79 years, uncontrolled baseline 24-hour ambulatory monitoring (ABPM). calculated from average day systolic measures. Results 78% (564 721). Factors that independently were: serum sodium >140mmol/l (OR=1.72, 95% CI: 1.17–2.51, p-value 0.005), higher office BP (OR=1.03, 1.01–1.05, 0.003) lower diastolic (OR=0.97, 0.95–0.99, 0.03). Treatment allocation did not change status months (McNemar's χ2 0.71, 0.40). Conclusion There high Africans hypertension. ABPM should considered more routinely hypertension, if resources permit, help personalise therapy. Further research needed understand mechanisms causes targeting night-time improves clinical outcomes. FUNDunding Acknowledgement Type funding sources: Public Institution(s). Main source(s): Fogarty International Center National Institutes Health United States America Figure 1